In the radiological examination of the spine one frequently sees in association with kyphoses very varied contours of the upper and lower vertebral margins. Mechanical Compression and Nucleus Pulposus Application on Dorsal Root the disc core is presumed to contribute to intervertebral disc hernia-related pain. This report examines 18 surgically proven L3/4 herniated nucleus pulposus ( HNP), all having myelogram, CT and adequate neurological evaluation. It will focus.

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Olmarker K, et al. In 28 rats, a syringe connected to a G injection needle was used to incise the disc and inject small volumes of air until NP leaked out and could be applied to the exposed DRG.

Lateral L3/4 herniated nucleus pulposus: clinical and imaging considerations.

The jelly-like contents of the disc then move into the spinal canal, pressing against the spinal nerves, which may produce intense and potentially disabling pain and other symptoms. When the spine is straight, such as in standing or lying down, internal pressure is equalized on all parts of the discs.

The cellular mechanisms behind the observed effects of light mechanical compression and NP exposure are not addressed in this study. The following locations have no discs and are therefore exempt from the risk of disc herniation: However, acute application of NP to a DRG without mechanical compression rapidly increases neuronal activity in the thalamus, a major brain relay nucleus processing information from sensory pathways including ascending nociceptive tracts.

With age the nucleus pulposus changes “dries out” and the risk of herniation is greatly reduced. It is composed of a thin lattice of collagen fibres type II which traverse though hydrophilic glycosaminoglycans. After positioning the recording electrode in the contralateral VPL nucleus a series of baseline records were obtained while stimulating the ipsilateral sciatic nerve. Education should emphasize not lifting beyond one’s capabilities and giving the body a rest after strenuous effort.


Future treatments may include stem cell therapy. Regarding the role of surgery for failed medical therapy in people without a significant neurological deficit, a Cochrane review concluded that “limited evidence is now available to support some aspects of surgical practice”. Disc herniation is frequently associated with age-related degeneration of the outer ring, known as the anulus fibrosusbut is normally triggered by trauma or straining by lifting or twisting.

We included both light mechanical compression of the DRG and exposure to NP, mimicking the clinical situation in which a disc protrusion may be followed by a rupture of the annulus fibrosus with subsequent NP leakage.

Roxanne Mae Birador SN; 2. In all animals, light mechanical compression of the DRG depressed the number of evoked neuronal responses. Specifically, the nucleus becomes fibrous and stiff and less able to bear load. The intervertebral disc is the largest avascular structure in the body.

Nucleus pulposus | Radiology Reference Article |

Pathomechanisms of nerve root injury caused by disc herniation: Author information Copyright and License information Disclaimer. Disc herniations can result from general wear and tear, such as constant sitting or squatting, driving, or a sedentary lifestyle.

Find articles by Elin Nilsson. Spinal cord disorders Bones of the vertebral column. Several ascending tracts carrying nociceptive information from the herniw cord to the brain are relayed in the thalamus 31 — 33 and changes in evoked neuronal responses in the VPL nucleus may thus reflect changes in activity in a number of nociceptive pathways. Since disc herniation surgery includes a mechanical decompression while the possible chemical effect of the disc material may remain, series 1 included subgroups in which the effects of applied NP were investigated at the level of the thalamus with and without remaining compression.

Nakanishi Y, et al. A recent study reported that NP applied to a DRG results in increased neuronal activity in the thalamus. Onda A, et al.

What is the abbreviation for Hernia Nukleus Pulposus?

Exercises that enhance back strength may also be used to prevent back injuries. A possible element in the pathogenesis of low-back pain. However, a statistical comparison of the raw data obtained as baseline records failed to reveal any significant differences between the experimental groups Kruskal—Wallis test; nonsignificant. Articles Cases Courses Quiz. Br J Gen Pract. Check for errors and try again. Introduction I ntervertebral disc hernia was first described by Mixter and Barr, 1 and the ensuing pain has been suggested to arise as a result of the mechanical compression that a ruptured disc exerts on adjacent nerves.


Other complications include chronic pain.

The most conclusive diagnostic tool for disc herniation is MRIand treatment may range from painkillers to surgery. They hukleus hernia nukleus pulposus from little or no pain if the disc is the only tissue injured, to severe uplposus unrelenting neck pain or low back pain that will radiate into the regions served by affected nerve roots that are irritated or impinged by the herniated material.

Smoking is a risk factor in the epidemiology of lumbar disk herniations and has pulpsus documented to decrease the oxygen tension in the avascular disk dramatically, presumably by hetnia and rheologic effects on blood. From Wikipedia, the free encyclopedia. CopyrightMary Ann Liebert, Inc.

Over-the-counter and hernia nukleus pulposus medications can often lessen inflammation, which allows patients to begin long-term treatments like physical therapy without excessive pain or discomfort. Unlike a pulsating pain or pain that comes and goes, which can be caused by muscle spasm, pain from a herniated disc is usually continuous or at least continuous in a specific position of the body.

Probable candidate genes include type I collagen sp1 sitetype IX collagenvitamin D receptoraggrecanasporinMMP3interleukin-1and interleukin-6 polymorphisms.