Diagnosis of Endometrial Biopsies and Curettings by Michael Mazur, , available at Book Depository with free delivery. Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach. Veli Marjoniemi. x. Veli Marjoniemi. Search for articles by this author. Department of. Generally, this should comprise a formal curetting rather than an outpatient biopsy. An external Diagnostic algorithm for examination of endometrial biopsies.

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It is useful to give some indication of the amount of endometrial tissue represented and the criteria for adequacy have already been discussed. Endometrioid carcinoma of the uterine corpus: Endometrial polyps, especially when large and occurring in elderly patients, should be carefully scrutinised for small serous proliferations.

Ckrettings J Gynecol Pathol 15 — Progestin treatment of atypical hyperplasia and well differentiated carcinoma of the endometrium in women under age Indeed, in the setting of chronic obstruction, squamous carcinoma of the endometrium may develop from florid squamous metaplasia.

Product details Format Hardback pages Dimensions x x Simple hyperplasia is usually a generalised condition, whereas most, but not all, cases of complex hyperplasia are focal, often occurring on a background of simple hyperplasia. A diagnosis of simple hyperplasia should not be made in the case of an endometrial polyp, as a glandular architecture reminiscent of simple hyperplasia is a normal feature within a polyp.

Pathology of endometrium treated with tamoxifen. Adenofibroma and adenosarcoma of the uterus: Gynecol Oncol 76 — Effects of tamoxifen on the endometrium Tamoxifen is widely used as adjuvant therapy in the management of breast cancer.

My approach to the interpretation of endometrial biopsies and curettings

The increasing use of pipelle and other methods of biopsy not necessitating general anaesthesia has resulted in greater numbers of specimens with scant tissue, resulting in problems in assessing adequacy and in interpreting artefactual changes, some of which appear more common with outpatient biopsies.


Dispatched from the UK in 3 business days When will my order arrive? Int J Gynecol Pathol 21 — In this review, the criteria for adequacy and common artefacts in endometrial biopsies, as well as the interpretation of endometrial biopsies in general, are discussed, concentrating on areas that cause problems for pathologists.

An adequate clinical history, including knowledge of the age, menstrual history and menopausal status, and information on the use of exogenous adn and tamoxifen, is necessary for the pathologist to critically evaluate endometrial biopsies. Hormone replacement therapy and the endometrium. Similar appearances occur with the Mirena coil, an intrauterine device containing progestogen, which is widely used.

Gynecol Oncol 55 — Looking for beautiful books? Focal mild glandular crowding is not uncommon and in my opinion does not warrant a diagnosis of complex endometrial hyperplasia. The most common endometrial lesions seen in association with tamoxifen are benign polyps, which may be single or multiple.

It furthers the University’s objective of curetrings in research, scholarship, and education by publishing worldwide. Citing articles via Google Scholar.

The gynaecologist may believe that a polyp is present, but histological examination shows a cyclical endometrium, often secretory in type, reflecting the fact that an abundant secretory endometrium may have a polypoid appearance. The glands within a polyp often show proliferative activity, even when the surrounding endometrium does not. Am J Surg Pathol 28 — An atrophic endometrium, which may or may not be an indication of the postmenopausal state atrophy is also characteristic of some hormonal agentsmay be confused with a proliferative endometrium, as the glands commonly have a tubular appearance and there may be apparent nuclear stratification.

A report of 19 cases.

My approach to the interpretation of endometrial biopsies and curettings

Obviously, if a cancer is identified in an endometrial polyp removed by biopsy, it is impossible to ascertain, without full evaluation of the surrounding endometrium, whether nedometrial cancer has arisen in or has secondarily involved the polyp. Royal Society of Medicine Press Ltd, The endometrial glands are positive but the stroma is negative.


Book ratings by Goodreads. Only a few comments will be made regarding atypical polypoid adenomyoma APAconcentrating on those issues that are likely to pertain to endometrial biopsy specimens.

Diagnosis of Endometrial Biopsies and Curettings : A Practical Approach

The presence of plasma cells is widely regarded as the most useful criterion for a diagnosis of endometritis, although these are often admixed with other inflammatory cells, both acute and chronic, and may be a minor component of the inflammatory cell infiltrate.

Inflammation of the endometrium. Am J Surg Pathol 23 — Diagnosis of Endometrial Biopsies and Curettings: Differentiating between an endometrioid and a serous carcinoma may be problematic on occasion. J Clin Pathol 55 — A major proportion of the workload in many histopathology laboratories is accounted endometrrial by endometrial biopsies, either curettage specimens or outpatient biopsy specimens.

In complex hyperplasia, there is an increase in the gland to stroma ratio with glandular crowding.

You do not currently have access to this article. By contrast, most metaplastic processes are oestrogen receptor positive and exhibit a weak heterogeneous pattern of p53 staining. A critical appraisal of the value of immunohistochemistry in the diagnosis of ovarian neoplasms.

Diagnosis of Endometrial Biopsies and Curettings : Michael Mazur :

Associated cytological atypia is usually mild or moderate. These metaplasias will not be discussed in detail, as they have been reviewed recently.

Opponents of the EIN system point out curttings implementation of this will require retraining pathologists and clinicians who will be confused by yet another classification of endometrial hyperplasia.

Results of a questionnaire regarding criteria for adequacy of endometrial biopsies. Color illustrations show typical artifacts and distortion, and explain their impact on diagnostic interpretation.